RETRACTED ARTICLE: Detection and replication of epistasis influencing transcription in humans

Gibran Hemani (), Konstantin Shakhbazov, Harm-Jan Westra, Tonu Esko, Anjali K. Henders, Allan F. McRae, Jian Yang, Greg Gibson, Nicholas G. Martin, Andres Metspalu, Lude Franke, Grant W. Montgomery, Peter M. Visscher and Joseph E. Powell
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Gibran Hemani: Queensland Brain Institute, University of Queensland
Konstantin Shakhbazov: Queensland Brain Institute, University of Queensland
Harm-Jan Westra: University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
Tonu Esko: Estonian Genome Center, University of Tartu, Tartu 51010, Estonia
Anjali K. Henders: Queensland Institute of Medical Research
Allan F. McRae: Queensland Brain Institute, University of Queensland
Jian Yang: Queensland Brain Institute, University of Queensland
Greg Gibson: School of Biology and Centre for Integrative Genomics, Georgia Institute of Technology
Nicholas G. Martin: Queensland Institute of Medical Research
Andres Metspalu: Estonian Genome Center, University of Tartu, Tartu 51010, Estonia
Lude Franke: University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
Grant W. Montgomery: Queensland Institute of Medical Research
Peter M. Visscher: Queensland Brain Institute, University of Queensland
Joseph E. Powell: Queensland Brain Institute, University of Queensland

Nature, 2014, vol. 508, issue 7495, 249-253

Abstract: Epistasis has rarely been shown among natural polymorphisms in human traits; this research using advanced computation and gene expression data reveals many instances of epistasis between common single nucleotide polymorphisms in humans, with epistasis and the direction of its effect replicating in independent cohorts.

Date: 2014
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DOI: 10.1038/nature13005

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