Direct measurement of local oxygen concentration in the bone marrow of live animals

Joel A. Spencer, Francesca Ferraro, Emmanuel Roussakis, Alyssa Klein, Juwell Wu, Judith M. Runnels, Walid Zaher, Luke J. Mortensen, Clemens Alt, Raphaël Turcotte, Rushdia Yusuf, Daniel Côté, Sergei A. Vinogradov, David T. Scadden and Charles P. Lin ()
Additional contact information
Joel A. Spencer: Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School
Francesca Ferraro: Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School
Emmanuel Roussakis: Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School
Alyssa Klein: Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School
Juwell Wu: Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School
Judith M. Runnels: Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School
Walid Zaher: Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School
Luke J. Mortensen: Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School
Clemens Alt: Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School
Raphaël Turcotte: Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School
Rushdia Yusuf: Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School
Daniel Côté: Génie Physique et Optique and Centre de Recherche de l’Institut Universitaire en Santé Mentale de Québec, Université Laval, Québec City, Québec G1J 2G3, Canada
Sergei A. Vinogradov: University of Pennsylvania
David T. Scadden: Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School
Charles P. Lin: Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School

Nature, 2014, vol. 508, issue 7495, 269-273

Abstract: Here, using two-photon phosphorescence lifetime microscopy, the local oxygen tension in the bone marrow of live mice is found to be quite low, with spatiotemporal variations depending on the blood vessel type, distance to the endosteum, and changes in cellularity after stress.

Date: 2014
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DOI: 10.1038/nature13034

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