Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity

Daniel Kraus, Qin Yang (), Dong Kong, Alexander S. Banks, Lin Zhang, Joseph T. Rodgers, Eija Pirinen, Thomas C. Pulinilkunnil, Fengying Gong, Ya-chin Wang, Yana Cen, Anthony A. Sauve, John M. Asara, Odile D. Peroni, Brett P. Monia, Sanjay Bhanot, Leena Alhonen, Pere Puigserver and Barbara B. Kahn ()
Additional contact information
Daniel Kraus: Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Qin Yang: Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Dong Kong: Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Alexander S. Banks: Dana-Farber Cancer Institute, Harvard Medical School
Lin Zhang: Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Joseph T. Rodgers: Dana-Farber Cancer Institute, Harvard Medical School
Eija Pirinen: Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, Kuopio Campus, PO Box 1627, FI-70211 Kuopio, Finland
Thomas C. Pulinilkunnil: Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Fengying Gong: Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Ya-chin Wang: Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Yana Cen: Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10065, USA
Anthony A. Sauve: Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10065, USA
John M. Asara: Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, Massachusetts 02215, USA
Odile D. Peroni: Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Brett P. Monia: Isis Pharmaceuticals, 1896 Rutherford Road
Sanjay Bhanot: Isis Pharmaceuticals, 1896 Rutherford Road
Leena Alhonen: Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, Kuopio Campus, PO Box 1627, FI-70211 Kuopio, Finland
Pere Puigserver: Dana-Farber Cancer Institute, Harvard Medical School
Barbara B. Kahn: Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA

Nature, 2014, vol. 508, issue 7495, 258-262

Abstract: Nicotinamide N-methyltransferase (NNMT) expression is increased in white adipose tissue and liver of obese and diabetic mice, Nnmt knockdown protects against diet-induced obesity by altering the availability of adipose S-adenosylmethionine and NAD+, rendering Nnmt a novel target for treating obesity and type 2 diabetes.

Date: 2014
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DOI: 10.1038/nature13198

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