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The ensemble nature of allostery

Hesam N. Motlagh, James O. Wrabl, Jing Li and Vincent J. Hilser ()
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Hesam N. Motlagh: Johns Hopkins University
James O. Wrabl: Johns Hopkins University
Jing Li: Johns Hopkins University
Vincent J. Hilser: Johns Hopkins University

Nature, 2014, vol. 508, issue 7496, 331-339

Abstract: Allostery is the process by which biological macromolecules transmit the effect of binding at one site to another, often distal, functional site, allowing for the regulation of activity; here facilitation of allostery through dynamic and intrinsically disordered proteins is discussed, and a framework to unify the description of allosteric mechanisms for different systems is proposed.

Date: 2014
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Citations: View citations in EconPapers (15)

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DOI: 10.1038/nature13001

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