Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430

Travis K. Warren, Jay Wells, Rekha G. Panchal, Kelly S. Stuthman, Nicole L. Garza, Sean A. Van Tongeren, Lian Dong, Cary J. Retterer, Brett P. Eaton, Gianluca Pegoraro, Shelley Honnold, Shanta Bantia, Pravin Kotian, Xilin Chen, Brian R. Taubenheim, Lisa S. Welch, Dena M. Minning, Yarlagadda S. Babu, William P. Sheridan and Sina Bavari ()
Additional contact information
Travis K. Warren: Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID)
Jay Wells: Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID)
Rekha G. Panchal: Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID)
Kelly S. Stuthman: Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID)
Nicole L. Garza: Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID)
Sean A. Van Tongeren: Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID)
Lian Dong: Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID)
Cary J. Retterer: Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID)
Brett P. Eaton: Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID)
Gianluca Pegoraro: Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID)
Shelley Honnold: Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID)
Shanta Bantia: BioCryst Pharmaceuticals Inc.
Pravin Kotian: BioCryst Pharmaceuticals Inc.
Xilin Chen: BioCryst Pharmaceuticals Inc.
Brian R. Taubenheim: BioCryst Pharmaceuticals Inc.
Lisa S. Welch: Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID)
Dena M. Minning: MedExpert Consulting, Inc.
Yarlagadda S. Babu: BioCryst Pharmaceuticals Inc.
William P. Sheridan: BioCryst Pharmaceuticals Inc.
Sina Bavari: Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID)

Nature, 2014, vol. 508, issue 7496, 402-405

Abstract: A broad-spectrum antiviral small molecule is reported to act as an inhibitor of viral polymerase activity and is shown to be effective in protecting non-human primates from lethal filovirus infection when administered after exposure.

Date: 2014
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DOI: 10.1038/nature13027

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