Rapid and tunable post-translational coupling of genetic circuits

Arthur Prindle, Jangir Selimkhanov, Howard Li, Ivan Razinkov, Lev S. Tsimring and Jeff Hasty ()
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Arthur Prindle: University of California, San Diego, La Jolla, California 92093, USA
Jangir Selimkhanov: University of California, San Diego, La Jolla, California 92093, USA
Howard Li: University of California, San Diego, La Jolla, California 92093, USA
Ivan Razinkov: University of California, San Diego, La Jolla, California 92093, USA
Lev S. Tsimring: BioCircuits Institute, University of California, San Diego, La Jolla, California 92093, USA
Jeff Hasty: University of California, San Diego, La Jolla, California 92093, USA

Nature, 2014, vol. 508, issue 7496, 387-391

Abstract: Protease competition is used to produce rapid and tunable coupling of genetic circuits, enabling a coupled clock network that can encode independent environmental cues into a single time series output, a form of frequency multiplexing in a genetic circuit context.

Date: 2014
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DOI: 10.1038/nature13238

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