Inhibition of miR-25 improves cardiac contractility in the failing heart

Christine Wahlquist, Dongtak Jeong, Agustin Rojas-Muñoz, Changwon Kho, Ahyoung Lee, Shinichi Mitsuyama, Alain van Mil, Woo Jin Park, Joost P. G. Sluijter, Pieter A. F. Doevendans, Roger J. Hajjar and Mark Mercola ()
Additional contact information
Christine Wahlquist: University of California, San Diego, and the Muscle Development and Regeneration Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
Dongtak Jeong: The Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai
Agustin Rojas-Muñoz: University of California, San Diego, and the Muscle Development and Regeneration Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
Changwon Kho: The Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai
Ahyoung Lee: The Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai
Shinichi Mitsuyama: The Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai
Alain van Mil: University of California, San Diego, and the Muscle Development and Regeneration Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
Woo Jin Park: Global Research Laboratory, Gwangju Institute of Science and Technology, 123 Cheomdan-gwagiro, Buk-gu, Gwangju 500-712, South Korea
Joost P. G. Sluijter: University Medical Center Utrecht and ICIN Netherlands Heart Institute, Heidelberglaan 100, room G02.523, 3584 CX Utrecht, The Netherlands
Pieter A. F. Doevendans: University Medical Center Utrecht and ICIN Netherlands Heart Institute, Heidelberglaan 100, room G02.523, 3584 CX Utrecht, The Netherlands
Roger J. Hajjar: The Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai
Mark Mercola: University of California, San Diego, and the Muscle Development and Regeneration Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA

Nature, 2014, vol. 508, issue 7497, 531-535

Abstract: Reduced activity of the calcium-transporting ATPase SERCA2a is a hallmark of heart failure; here, microRNAs that downregulate SERCA2a function are identified, and antagonism of one, miR-25, is shown to halt heart failure in mice.

Date: 2014
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DOI: 10.1038/nature13073

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