Trogocytosis by Entamoeba histolytica contributes to cell killing and tissue invasion

Katherine S. Ralston, Michael D. Solga, Nicole M. Mackey-Lawrence, Somlata, Alok Bhattacharya and William A. Petri ()
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Katherine S. Ralston: University of Virginia
Michael D. Solga: Immunology and Cancer Biology, University of Virginia
Nicole M. Mackey-Lawrence: University of Virginia
Somlata: School of Life Sciences, Jawaharlal Nehru University, 110067 New Delhi, India
Alok Bhattacharya: School of Life Sciences, Jawaharlal Nehru University, 110067 New Delhi, India
William A. Petri: University of Virginia

Nature, 2014, vol. 508, issue 7497, 526-530

Abstract: Entamoeba histolytica, the causative agent of fatal diarrhoeal disease in children in the developing world, is shown here to kill human cells by biting off and ingesting pieces of cells, in a process reminiscent of the trogocytosis seen between immune cells; ingestion of bites is required for killing and this mechanism is used both in tissue culture and during invasion of intestinal explants.

Date: 2014
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DOI: 10.1038/nature13242

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