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Nuclear reprogramming by interphase cytoplasm of two-cell mouse embryos

Eunju Kang, Guangming Wu, Hong Ma, Ying Li, Rebecca Tippner-Hedges, Masahito Tachibana, Michelle Sparman, Don P. Wolf, Hans R. Schöler and Shoukhrat Mitalipov ()
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Eunju Kang: Oregon National Primate Research Center, Oregon Health & Science University
Guangming Wu: Max Planck Institute for Molecular Biomedicine, Münster 48149, Germany
Hong Ma: Oregon National Primate Research Center, Oregon Health & Science University
Ying Li: Oregon National Primate Research Center, Oregon Health & Science University
Rebecca Tippner-Hedges: Oregon National Primate Research Center, Oregon Health & Science University
Masahito Tachibana: Oregon National Primate Research Center, Oregon Health & Science University
Michelle Sparman: Oregon National Primate Research Center, Oregon Health & Science University
Don P. Wolf: Oregon National Primate Research Center, Oregon Health & Science University
Hans R. Schöler: Max Planck Institute for Molecular Biomedicine, Münster 48149, Germany
Shoukhrat Mitalipov: Oregon National Primate Research Center, Oregon Health & Science University

Nature, 2014, vol. 509, issue 7498, 101-104

Abstract: Reprogramming after somatic cell nuclear transfer had been thought to be dependent on the recipient cytoplasm being arrested at the metaphase stage, but here interphase two-cell mouse embryos are shown to support successful reprogramming and generation of embryonic stem cells or cloned mice.

Date: 2014
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DOI: 10.1038/nature13134

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