Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I

Alys Peisley, Bin Wu, Hui Xu, Zhijian J. Chen and Sun Hur ()
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Alys Peisley: Harvard Medical School
Bin Wu: Harvard Medical School
Hui Xu: University of Texas Southwestern Medical Center
Zhijian J. Chen: University of Texas Southwestern Medical Center
Sun Hur: Harvard Medical School

Nature, 2014, vol. 509, issue 7498, 110-114

Abstract: RIG-I protein recognizes viral duplex RNA with a 5′-triphosphate group, activating innate immune responses; a crystal structure of its tetrameric CARD signalling domain reveals that non-covalently linked ubiquitin chains stabilize the tetramer in a ‘lock-washer’ structure that serves as a signalling platform for the recruitment and activation of MAVS.

Date: 2014
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DOI: 10.1038/nature13140

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