Endosomes are specialized platforms for bacterial sensing and NOD2 signalling

Norihiro Nakamura, Jennie R. Lill, Qui Phung, Zhaoshi Jiang, Corey Bakalarski, Ann de Mazière, Judith Klumperman, Megan Schlatter, Lélia Delamarre and Ira Mellman ()
Additional contact information
Norihiro Nakamura: Genentech, 1 DNA Way
Jennie R. Lill: Genentech, 1 DNA Way
Qui Phung: Genentech, 1 DNA Way
Zhaoshi Jiang: Genentech, 1 DNA Way
Corey Bakalarski: Genentech, 1 DNA Way
Ann de Mazière: University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
Judith Klumperman: University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
Megan Schlatter: Genentech, 1 DNA Way
Lélia Delamarre: Genentech, 1 DNA Way
Ira Mellman: Genentech, 1 DNA Way

Nature, 2014, vol. 509, issue 7499, 240-244

Abstract: The endo-lysosomal transporters SLC15A3 and SLC15A4 provide a portal of entry for extracellular bacterial products that activate the cytoplasmic sensor NOD2; these results establish the importance of endosomes as signalling platforms specialized for triggering innate immune responses.

Date: 2014
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DOI: 10.1038/nature13133

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