NRROS negatively regulates reactive oxygen species during host defence and autoimmunity

Rajkumar Noubade, Kit Wong, Naruhisa Ota, Sascha Rutz, Celine Eidenschenk, Patricia A. Valdez, Jiabing Ding, Ivan Peng, Andrew Sebrell, Patrick Caplazi, Jason DeVoss, Robert H. Soriano, Tao Sai, Rongze Lu, Zora Modrusan, Jason Hackney and Wenjun Ouyang ()
Additional contact information
Rajkumar Noubade: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Kit Wong: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Naruhisa Ota: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Sascha Rutz: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Celine Eidenschenk: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Patricia A. Valdez: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Jiabing Ding: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Ivan Peng: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Andrew Sebrell: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Patrick Caplazi: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Jason DeVoss: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Robert H. Soriano: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Tao Sai: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Rongze Lu: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Zora Modrusan: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Jason Hackney: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Wenjun Ouyang: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA

Nature, 2014, vol. 509, issue 7499, 235-239

Abstract: The leucine-rich repeat protein NRROS which resides in the endoplasmic reticulum regulates phagocytic NADPH oxidase, minimizing collateral tissue damage caused by reactive oxygen species during inflammatory processes.

Date: 2014
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DOI: 10.1038/nature13152

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