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Signal amplification and transduction in phytochrome photosensors

Heikki Takala, Alexander Björling, Oskar Berntsson, Heli Lehtivuori, Stephan Niebling, Maria Hoernke, Irina Kosheleva, Robert Henning, Andreas Menzel, Janne A. Ihalainen () and Sebastian Westenhoff ()
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Heikki Takala: Nanoscience Center, University of Jyväskylä, 40014 Jyväskylä, Finland
Alexander Björling: University of Gothenburg, 40530 Gothenburg, Sweden
Oskar Berntsson: University of Gothenburg, 40530 Gothenburg, Sweden
Heli Lehtivuori: Nanoscience Center, University of Jyväskylä, 40014 Jyväskylä, Finland
Stephan Niebling: University of Gothenburg, 40530 Gothenburg, Sweden
Maria Hoernke: University of Gothenburg, 40530 Gothenburg, Sweden
Irina Kosheleva: Center for Advanced Radiation Sources, The University of Chicago
Robert Henning: Center for Advanced Radiation Sources, The University of Chicago
Andreas Menzel: Paul Scherrer Institut, 5232 Villigen PSI, Switzerland
Janne A. Ihalainen: Nanoscience Center, University of Jyväskylä, 40014 Jyväskylä, Finland
Sebastian Westenhoff: University of Gothenburg, 40530 Gothenburg, Sweden

Nature, 2014, vol. 509, issue 7499, 245-248

Abstract: The solution and crystal structures of a bacterial phytochrome photosensory core in both its resting and activated states are determined; switching between closed (resting) and open (activated) forms is found to be mediated by a conserved ‘tongue’, and the structures indicate that smaller changes in the vicinity of the chromophore are amplified in scale as they are transmitted through the tongue and beyond.

Date: 2014
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DOI: 10.1038/nature13310

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