Nucleotide signalling during inflammation

Marco Idzko (), Davide Ferrari and Holger K. Eltzschig
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Marco Idzko: Freiburg University Medical Center, Albert-Ludwigs-University, 79106 Freiburg, Germany
Davide Ferrari: Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, University of Ferrara, Ferrara, 44121, Italy
Holger K. Eltzschig: Organ Protection Program, University of Colorado School of Medicine

Nature, 2014, vol. 509, issue 7500, 310-317

Abstract: Extracellular ATP released from cells during inflammatory responses predominantly functions as a signalling molecule through the activation of purinergic P2 receptors and contributes to both beneficial and detrimental inflammatory responses; this review examines P2 receptor signalling via ATP and its effect on the outcome of inflammatory and infectious diseases.

Date: 2014
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DOI: 10.1038/nature13085

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