Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

Etienne Meunier, Mathias S. Dick, Roland F. Dreier, Nura Schürmann, Daniela Kenzelmann Broz, Søren Warming, Merone Roose-Girma, Dirk Bumann, Nobuhiko Kayagaki, Kiyoshi Takeda, Masahiro Yamamoto and Petr Broz ()
Additional contact information
Etienne Meunier: Focal Area Infection Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland
Mathias S. Dick: Focal Area Infection Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland
Roland F. Dreier: Focal Area Infection Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland
Nura Schürmann: Focal Area Infection Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland
Daniela Kenzelmann Broz: University of Basel, CH-4056 Basel, Switzerland
Søren Warming: Genentech Inc.
Merone Roose-Girma: Genentech Inc.
Dirk Bumann: Focal Area Infection Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland
Nobuhiko Kayagaki: Genentech Inc.
Kiyoshi Takeda: Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan
Masahiro Yamamoto: Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan
Petr Broz: Focal Area Infection Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland

Nature, 2014, vol. 509, issue 7500, 366-370

Abstract: Interferon-inducible GTPases are required for the release of vacuolar Gram-negative bacteria into the cytoplasm and subsequent inflammasome-mediated caspase-11 activation.

Date: 2014
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DOI: 10.1038/nature13157

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