T-cell activation by transitory neo-antigens derived from distinct microbial pathways

Alexandra J. Corbett, Sidonia B. G. Eckle, Richard W. Birkinshaw, Ligong Liu, Onisha Patel, Jennifer Mahony, Zhenjun Chen, Rangsima Reantragoon, Bronwyn Meehan, Hanwei Cao, Nicholas A. Williamson, Richard A. Strugnell, Douwe Van Sinderen, Jeffrey Y. W. Mak, David P. Fairlie (), Lars Kjer-Nielsen (), Jamie Rossjohn () and James McCluskey ()
Additional contact information
Alexandra J. Corbett: Peter Doherty Institute for Infection and Immunity, University of Melbourne
Sidonia B. G. Eckle: Peter Doherty Institute for Infection and Immunity, University of Melbourne
Richard W. Birkinshaw: School of Biomedical Sciences, Monash University
Ligong Liu: Institute for Molecular Bioscience, The University of Queensland
Onisha Patel: School of Biomedical Sciences, Monash University
Jennifer Mahony: School of Microbiology, University College Cork
Zhenjun Chen: Peter Doherty Institute for Infection and Immunity, University of Melbourne
Rangsima Reantragoon: Peter Doherty Institute for Infection and Immunity, University of Melbourne
Bronwyn Meehan: Peter Doherty Institute for Infection and Immunity, University of Melbourne
Hanwei Cao: Peter Doherty Institute for Infection and Immunity, University of Melbourne
Nicholas A. Williamson: The Bio21 Molecular Science and Biotechnology Institute, University of Melbourne
Richard A. Strugnell: Peter Doherty Institute for Infection and Immunity, University of Melbourne
Douwe Van Sinderen: School of Microbiology, University College Cork
Jeffrey Y. W. Mak: Institute for Molecular Bioscience, The University of Queensland
David P. Fairlie: Institute for Molecular Bioscience, The University of Queensland
Lars Kjer-Nielsen: Peter Doherty Institute for Infection and Immunity, University of Melbourne
Jamie Rossjohn: School of Biomedical Sciences, Monash University
James McCluskey: Peter Doherty Institute for Infection and Immunity, University of Melbourne

Nature, 2014, vol. 509, issue 7500, 361-365

Abstract: Activation of mucosal-associated invariant T (MAIT) cells is shown to require key genes encoding an early intermediate in bacterial riboflavin synthesis, 5-amino-6-d-ribitylaminouracil; this reacts non-enzymatically with metabolites to form short-lived antigens that are captured and stabilized by MR1 for presentation to MAIT cells.

Date: 2014
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DOI: 10.1038/nature13160

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