A semi-synthetic organism with an expanded genetic alphabet

Denis A. Malyshev, Kirandeep Dhami, Thomas Lavergne, Tingjian Chen, Nan Dai, Jeremy M. Foster, Ivan R. Corrêa and Floyd E. Romesberg ()
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Denis A. Malyshev: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Kirandeep Dhami: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Thomas Lavergne: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Tingjian Chen: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Nan Dai: New England Biolabs, 240 County Road
Jeremy M. Foster: New England Biolabs, 240 County Road
Ivan R. Corrêa: New England Biolabs, 240 County Road
Floyd E. Romesberg: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA

Nature, 2014, vol. 509, issue 7500, 385-388

Abstract: Triphosphates of hydrophobic nucleotides d5SICS and dNaM are imported into Escherichia coli by an exogenous algal nucleotide triphosphate transporter and then used by an endogenous polymerase to replicate, and faithfully maintain over many generations of growth, a plasmid containing the d5SICS–dNaM unnatural base pair.

Date: 2014
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DOI: 10.1038/nature13314

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