Protective mucosal immunity mediated by epithelial CD1d and IL-10

Torsten Olszak, Joana F. Neves, C. Marie Dowds, Kristi Baker, Jonathan Glickman, Nicholas O. Davidson, Chyuan-Sheng Lin, Christian Jobin, Stephan Brand, Karl Sotlar, Koichiro Wada, Kazufumi Katayama, Atsushi Nakajima, Hiroyuki Mizuguchi, Kunito Kawasaki, Kazuhiro Nagata, Werner Müller, Scott B. Snapper, Stefan Schreiber, Arthur Kaser, Sebastian Zeissig () and Richard S. Blumberg ()
Additional contact information
Torsten Olszak: Hepatology, and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School
Joana F. Neves: Hepatology, and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School
C. Marie Dowds: University Medical Center Schleswig-Holstein, 24105 Kiel, Germany
Kristi Baker: Hepatology, and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School
Jonathan Glickman: GI Pathology, Miraca Life Sciences
Nicholas O. Davidson: Washington University School of Medicine
Chyuan-Sheng Lin: Herbert Irving Comprehensive Cancer Center, Columbia University
Christian Jobin: University of Florida
Stephan Brand: Ludwig Maximilians University, Munich 81377, Germany
Karl Sotlar: Institute of Pathology, Ludwig Maximilians University, Munich 80337, Germany
Koichiro Wada: Graduate School of Dentistry, Osaka University, Osaka 565-0871, Japan
Kazufumi Katayama: Graduate School of Dentistry, Osaka University, Osaka 565-0871, Japan
Atsushi Nakajima: Yokohama City University School of Medicine, Yokohama, Kanagawa 236-0027, Japan
Hiroyuki Mizuguchi: Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan
Kunito Kawasaki: Faculty of Life Sciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555, Japan
Kazuhiro Nagata: Faculty of Life Sciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555, Japan
Werner Müller: Faculty of Life Sciences, University of Manchester, Manchester M13 9PL, UK
Scott B. Snapper: Hepatology, and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School
Stefan Schreiber: University Medical Center Schleswig-Holstein, 24105 Kiel, Germany
Arthur Kaser: Addenbrooke Hospital, University of Cambridge, Cambridge CB2 0QQ, UK
Sebastian Zeissig: Hepatology, and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School
Richard S. Blumberg: Hepatology, and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School

Nature, 2014, vol. 509, issue 7501, 497-502

Abstract: Here, the presentation of lipid antigens by CD1d is shown to induce retrograde anti-inflammatory signalling in intestinal epithelial cells, resulting in the production of IL-10.

Date: 2014
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DOI: 10.1038/nature13150

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