Copper is required for oncogenic BRAF signalling and tumorigenesis

Donita C. Brady, Matthew S. Crowe, Michelle L. Turski, G. Aaron Hobbs, Xiaojie Yao, Apirat Chaikuad, Stefan Knapp, Kunhong Xiao, Sharon L. Campbell, Dennis J. Thiele and Christopher M. Counter ()
Additional contact information
Donita C. Brady: Duke University Medical Center
Matthew S. Crowe: Duke University Medical Center
Michelle L. Turski: Duke University Medical Center
G. Aaron Hobbs: University of North Carolina at Chapel Hill
Xiaojie Yao: Duke University Medical Center
Apirat Chaikuad: Target Discovery Institute and Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK
Stefan Knapp: Target Discovery Institute and Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK
Kunhong Xiao: Duke University Medical Center
Sharon L. Campbell: University of North Carolina at Chapel Hill
Dennis J. Thiele: Duke University Medical Center
Christopher M. Counter: Duke University Medical Center

Nature, 2014, vol. 509, issue 7501, 492-496

Abstract: Tumorigenesis driven by the oncogene BRAFV600E is shown both to depend on the BRAF substrates MEK1/2 associating with copper, and to be sensitive to copper-chelating drugs, suggesting merit in testing such drugs for the treatment of BRAF mutation-positive cancers.

Date: 2014
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DOI: 10.1038/nature13180

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