Structure of the AcrAB–TolC multidrug efflux pump

Dijun Du (), Zhao Wang, Nathan R. James, Jarrod E. Voss, Ewa Klimont, Thelma Ohene-Agyei, Henrietta Venter, Wah Chiu and Ben F. Luisi ()
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Dijun Du: University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK
Zhao Wang: National Center for Macromolecular Imaging, Baylor College of Medicine
Nathan R. James: University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK
Jarrod E. Voss: University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK
Ewa Klimont: University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK
Thelma Ohene-Agyei: Tennis Court Road, Cambridge CB2 1PD, UK
Henrietta Venter: School of Pharmacy & Medical Sciences, Sansom Institute for Health Research, University of South Australia
Wah Chiu: National Center for Macromolecular Imaging, Baylor College of Medicine
Ben F. Luisi: University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK

Nature, 2014, vol. 509, issue 7501, 512-515

Abstract: Many bacteria are able to survive in the presence of antibiotics in part because they possess pumps that can remove a broad range of small molecules; here, the structure of one such pump, AcrAB–TolC, is determined using X-ray crystallography and cryo-electron microscopy.

Date: 2014
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DOI: 10.1038/nature13205

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