Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

Long N. Nguyen, Dongliang Ma, Guanghou Shui, Peiyan Wong, Amaury Cazenave-Gassiot, Xiaodong Zhang, Markus R. Wenk, Eyleen L. K. Goh and David L. Silver ()
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Long N. Nguyen: Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-NUS Graduate Medical School Singapore, 8 College Road, 169857 Singapore
Dongliang Ma: Signature Research Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School Singapore, 8 College Road, 169857 Singapore
Guanghou Shui: National University of Singapore, 8 Medical Drive, Block MD7, 117597 Singapore
Peiyan Wong: Signature Research Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School Singapore, 8 College Road, 169857 Singapore
Amaury Cazenave-Gassiot: National University of Singapore, 8 Medical Drive, Block MD7, 117597 Singapore
Xiaodong Zhang: Signature Research Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School Singapore, 8 College Road, 169857 Singapore
Markus R. Wenk: National University of Singapore, 8 Medical Drive, Block MD7, 117597 Singapore
Eyleen L. K. Goh: Signature Research Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School Singapore, 8 College Road, 169857 Singapore
David L. Silver: Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-NUS Graduate Medical School Singapore, 8 College Road, 169857 Singapore

Nature, 2014, vol. 509, issue 7501, 503-506

Abstract: Mfsd2a is the major transporter of the omega-3 fatty acid docosahexaenoic acid (DHA) into brain, with Mfsd2a-knockout mice showing reduced DHA in brain, neuronal cell loss in hippocampus and cerebellum, behavioural disorders and reduced brain size; DHA is transported in a sodium-dependent manner, in the form of lysophosphatidylcholines (LPCs) carrying long-chain fatty acids.

Date: 2014
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DOI: 10.1038/nature13241

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