Mfsd2a is critical for the formation and function of the blood–brain barrier

Ayal Ben-Zvi, Baptiste Lacoste, Esther Kur, Benjamin J. Andreone, Yoav Mayshar, Han Yan and Chenghua Gu ()
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Ayal Ben-Zvi: Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
Baptiste Lacoste: Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
Esther Kur: Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
Benjamin J. Andreone: Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
Yoav Mayshar: Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
Han Yan: Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
Chenghua Gu: Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA

Nature, 2014, vol. 509, issue 7501, 507-511

Abstract: Mfsd2a is a key regulator of blood–brain barrier (BBB) formation and function in mice: Mfsd2a is selectively expressed in BBB-containing blood vessels in the CNS; Mfsd2a−/− mice have a leaky BBB and increased vesicular transcytosis in CNS endothelial cells; and Mfsd2a endothelial expression is regulated by pericytes to facilitate BBB integrity.

Date: 2014
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DOI: 10.1038/nature13324

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