Scalable control of mounting and attack by Esr1+ neurons in the ventromedial hypothalamus

Hyosang Lee, Dong-Wook Kim, Ryan Remedios, Todd E. Anthony, Angela Chang, Linda Madisen, Hongkui Zeng and David J. Anderson ()
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Hyosang Lee: California Institute of Technology
Dong-Wook Kim: Computation and Neural Systems, California Institute of Technology
Ryan Remedios: California Institute of Technology
Todd E. Anthony: California Institute of Technology
Angela Chang: California Institute of Technology
Linda Madisen: Allen Institute for Brain Science
Hongkui Zeng: Allen Institute for Brain Science
David J. Anderson: California Institute of Technology

Nature, 2014, vol. 509, issue 7502, 627-632

Abstract: Activation of Esr1+ neurons of the mouse ventromedial hypothalamus initiates graded social behavioural responses–weak activation triggers close investigation (sniffing) during a social encounter that often leads, with continued stimulation, to mounting behaviours by males towards either gender; mounting behaviour transitions to aggressive attacks with greater stimulation intensity.

Date: 2014
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DOI: 10.1038/nature13169

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