Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors

Srdjan Maksimovic, Masashi Nakatani, Yoshichika Baba, Aislyn M. Nelson, Kara L. Marshall, Scott A. Wellnitz, Pervez Firozi, Seung-Hyun Woo, Sanjeev Ranade, Ardem Patapoutian and Ellen A. Lumpkin ()
Additional contact information
Srdjan Maksimovic: Columbia University
Masashi Nakatani: Columbia University
Yoshichika Baba: Columbia University
Aislyn M. Nelson: Columbia University
Kara L. Marshall: Columbia University
Scott A. Wellnitz: Baylor College of Medicine
Pervez Firozi: Baylor College of Medicine
Seung-Hyun Woo: Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, The Scripps Research Institute
Sanjeev Ranade: Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, The Scripps Research Institute
Ardem Patapoutian: Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, The Scripps Research Institute
Ellen A. Lumpkin: Columbia University

Nature, 2014, vol. 509, issue 7502, 617-621

Abstract: The cellular basis of touch has long been debated, in particular the relationship between sensory neurons and non-neuronal cells; a mouse study uses optogenetics to identify their distinct and collaborative roles, with skin-derived Merkel cells both transducing touch and actively tuning responses of touch-sensitive neurons.

Date: 2014
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DOI: 10.1038/nature13250

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