Piezo2 is required for Merkel-cell mechanotransduction

Seung-Hyun Woo, Sanjeev Ranade, Andy D. Weyer, Adrienne E. Dubin, Yoshichika Baba, Zhaozhu Qiu, Matt Petrus, Takashi Miyamoto, Kritika Reddy, Ellen A. Lumpkin, Cheryl L. Stucky and Ardem Patapoutian ()
Additional contact information
Seung-Hyun Woo: Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, The Scripps Research Institute
Sanjeev Ranade: Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, The Scripps Research Institute
Andy D. Weyer: Neurobiology, and Anatomy, Medical College of Wisconsin
Adrienne E. Dubin: Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, The Scripps Research Institute
Yoshichika Baba: Columbia University
Zhaozhu Qiu: Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, The Scripps Research Institute
Matt Petrus: Genomics Institute of the Novartis Research Foundation
Takashi Miyamoto: Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, The Scripps Research Institute
Kritika Reddy: Genomics Institute of the Novartis Research Foundation
Ellen A. Lumpkin: Columbia University
Cheryl L. Stucky: Neurobiology, and Anatomy, Medical College of Wisconsin
Ardem Patapoutian: Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, The Scripps Research Institute

Nature, 2014, vol. 509, issue 7502, 622-626

Abstract: A mouse study shows that non-neuronal epidermal Merkel cells aid fine-touch perception in the skin through their expression of the Piezo2 mechanosensitive cation channel which then actively tunes the response to touch in adjacent somatosensory neurons.

Date: 2014
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DOI: 10.1038/nature13251

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