A draft map of the human proteome

Min-Sik Kim, Sneha M. Pinto, Derese Getnet, Raja Sekhar Nirujogi, Srikanth S. Manda, Raghothama Chaerkady, Anil K. Madugundu, Dhanashree S. Kelkar, Ruth Isserlin, Shobhit Jain, Joji K. Thomas, Babylakshmi Muthusamy, Pamela Leal-Rojas, Praveen Kumar, Nandini A. Sahasrabuddhe, Lavanya Balakrishnan, Jayshree Advani, Bijesh George, Santosh Renuse, Lakshmi Dhevi N. Selvan, Arun H. Patil, Vishalakshi Nanjappa, Aneesha Radhakrishnan, Samarjeet Prasad, Tejaswini Subbannayya, Rajesh Raju, Manish Kumar, Sreelakshmi K. Sreenivasamurthy, Arivusudar Marimuthu, Gajanan J. Sathe, Sandip Chavan, Keshava K. Datta, Yashwanth Subbannayya, Apeksha Sahu, Soujanya D. Yelamanchi, Savita Jayaram, Pavithra Rajagopalan, Jyoti Sharma, Krishna R. Murthy, Nazia Syed, Renu Goel, Aafaque A. Khan, Sartaj Ahmad, Gourav Dey, Keshav Mudgal, Aditi Chatterjee, Tai-Chung Huang, Jun Zhong, Xinyan Wu, Patrick G. Shaw, Donald Freed, Muhammad S. Zahari, Kanchan K. Mukherjee, Subramanian Shankar, Anita Mahadevan, Henry Lam, Christopher J. Mitchell, Susarla Krishna Shankar, Parthasarathy Satishchandra, John T. Schroeder, Ravi Sirdeshmukh, Anirban Maitra, Steven D. Leach, Charles G. Drake, Marc K. Halushka, T. S. Keshava Prasad, Ralph H. Hruban, Candace L. Kerr, Gary D. Bader, Christine A. Iacobuzio-Donahue, Harsha Gowda () and Akhilesh Pandey ()
Additional contact information
Min-Sik Kim: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
Sneha M. Pinto: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Derese Getnet: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
Raja Sekhar Nirujogi: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Srikanth S. Manda: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Raghothama Chaerkady: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
Anil K. Madugundu: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Dhanashree S. Kelkar: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Ruth Isserlin: The Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada
Shobhit Jain: The Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada
Joji K. Thomas: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Babylakshmi Muthusamy: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Pamela Leal-Rojas: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
Praveen Kumar: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Nandini A. Sahasrabuddhe: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Lavanya Balakrishnan: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Jayshree Advani: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Bijesh George: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Santosh Renuse: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Lakshmi Dhevi N. Selvan: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Arun H. Patil: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Vishalakshi Nanjappa: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Aneesha Radhakrishnan: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Samarjeet Prasad: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
Tejaswini Subbannayya: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Rajesh Raju: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Manish Kumar: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Sreelakshmi K. Sreenivasamurthy: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Arivusudar Marimuthu: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Gajanan J. Sathe: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Sandip Chavan: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Keshava K. Datta: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Yashwanth Subbannayya: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Apeksha Sahu: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Soujanya D. Yelamanchi: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Savita Jayaram: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Pavithra Rajagopalan: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Jyoti Sharma: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Krishna R. Murthy: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Nazia Syed: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Renu Goel: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Aafaque A. Khan: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Sartaj Ahmad: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Gourav Dey: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Keshav Mudgal: School of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
Aditi Chatterjee: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Tai-Chung Huang: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
Jun Zhong: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
Xinyan Wu: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
Patrick G. Shaw: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
Donald Freed: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
Muhammad S. Zahari: Johns Hopkins University School of Medicine
Kanchan K. Mukherjee: Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India
Subramanian Shankar: Pune 411040, India
Anita Mahadevan: National Institute of Mental Health and Neurosciences, Bangalore 560029, India
Henry Lam: The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong
Christopher J. Mitchell: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
Susarla Krishna Shankar: National Institute of Mental Health and Neurosciences, Bangalore 560029, India
Parthasarathy Satishchandra: National Institute of Mental Health and Neurosciences, Bangalore 560029, India
John T. Schroeder: Johns Hopkins University School of Medicine
Ravi Sirdeshmukh: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Anirban Maitra: The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine
Steven D. Leach: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
Charles G. Drake: Johns Hopkins University School of Medicine
Marc K. Halushka: The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine
T. S. Keshava Prasad: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Ralph H. Hruban: The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine
Candace L. Kerr: Johns Hopkins University School of Medicine Baltimore
Gary D. Bader: The Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada
Christine A. Iacobuzio-Donahue: The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine
Harsha Gowda: Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
Akhilesh Pandey: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine

Nature, 2014, vol. 509, issue 7502, 575-581

Abstract: Abstract The availability of human genome sequence has transformed biomedical research over the past decade. However, an equivalent map for the human proteome with direct measurements of proteins and peptides does not exist yet. Here we present a draft map of the human proteome using high-resolution Fourier-transform mass spectrometry. In-depth proteomic profiling of 30 histologically normal human samples, including 17 adult tissues, 7 fetal tissues and 6 purified primary haematopoietic cells, resulted in identification of proteins encoded by 17,294 genes accounting for approximately 84% of the total annotated protein-coding genes in humans. A unique and comprehensive strategy for proteogenomic analysis enabled us to discover a number of novel protein-coding regions, which includes translated pseudogenes, non-coding RNAs and upstream open reading frames. This large human proteome catalogue (available as an interactive web-based resource at http://www.humanproteomemap.org ) will complement available human genome and transcriptome data to accelerate biomedical research in health and disease.

Date: 2014
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DOI: 10.1038/nature13302

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