Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation

Lorena Riol-Blanco, Jose Ordovas-Montanes, Mario Perro, Elena Naval, Aude Thiriot, David Alvarez, Silke Paust, John N. Wood and Ulrich H. von Andrian ()
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Lorena Riol-Blanco: Harvard Medical School
Jose Ordovas-Montanes: Harvard Medical School
Mario Perro: Harvard Medical School
Elena Naval: Harvard Medical School
Aude Thiriot: Harvard Medical School
David Alvarez: Harvard Medical School
Silke Paust: Harvard Medical School
John N. Wood: Institute for Biomedical Research, University College London, London WC1E 6BT, UK
Ulrich H. von Andrian: Harvard Medical School

Nature, 2014, vol. 510, issue 7503, 157-161

Abstract: In mice, it is possible to induce a psoriasis-like condition by applying imiquimod; here, the production of interleukin-23 that is stimulated by such skin inflammation is shown to depend on the interaction of nociceptors expressing the Nav1.8 and TRPV1 channels with skin-resident dendritic cells.

Date: 2014
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DOI: 10.1038/nature13199

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