Oncogene-like induction of cellular invasion from centrosome amplification

Susana A. Godinho (), Remigio Picone, Mithila Burute, Regina Dagher, Ying Su, Cheuk T. Leung, Kornelia Polyak, Joan S. Brugge, Manuel Théry and David Pellman ()
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Susana A. Godinho: Howard Hughes Medical Institute, Dana-Farber Cancer Institute and Pediatric Hematology/Oncology, Children’s Hospital
Remigio Picone: Howard Hughes Medical Institute, Dana-Farber Cancer Institute and Pediatric Hematology/Oncology, Children’s Hospital
Mithila Burute: Institut de Recherche en Technologie et Science pour le Vivant, UMR5168 CEA/UJF/INRA/CNRS, Grenoble, France
Regina Dagher: Howard Hughes Medical Institute, Dana-Farber Cancer Institute and Pediatric Hematology/Oncology, Children’s Hospital
Ying Su: Dana-Farber Cancer Institute, Harvard Medical School
Cheuk T. Leung: Harvard Medical School
Kornelia Polyak: Dana-Farber Cancer Institute, Harvard Medical School
Joan S. Brugge: Harvard Medical School
Manuel Théry: Institut de Recherche en Technologie et Science pour le Vivant, UMR5168 CEA/UJF/INRA/CNRS, Grenoble, France
David Pellman: Howard Hughes Medical Institute, Dana-Farber Cancer Institute and Pediatric Hematology/Oncology, Children’s Hospital

Nature, 2014, vol. 510, issue 7503, 167-171

Abstract: Cancer cells often have extra centrosomes, a paradox considering the detrimental effect extra centrosomes usually have on cell division; a study of human cells reveals that extra centrosomes can promote cancer cell invasion phenotypes through a pathway involving increased microtubule nucleation and Rac1 activity.

Date: 2014
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DOI: 10.1038/nature13277

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