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Focused specificity of intestinal TH17 cells towards commensal bacterial antigens

Yi Yang, Miriam B. Torchinsky, Michael Gobert, Huizhong Xiong, Mo Xu, Jonathan L. Linehan, Francis Alonzo, Charles Ng, Alessandra Chen, Xiyao Lin, Andrew Sczesnak, Jia-Jun Liao, Victor J. Torres, Marc K. Jenkins, Juan J. Lafaille and Dan R. Littman ()
Additional contact information
Yi Yang: The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
Miriam B. Torchinsky: The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
Michael Gobert: The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
Huizhong Xiong: The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
Mo Xu: The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
Jonathan L. Linehan: Center for Immunology, University of Minnesota Medical School
Francis Alonzo: New York University School of Medicine
Charles Ng: The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
Alessandra Chen: The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
Xiyao Lin: The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
Andrew Sczesnak: The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
Jia-Jun Liao: The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
Victor J. Torres: New York University School of Medicine
Marc K. Jenkins: Center for Immunology, University of Minnesota Medical School
Juan J. Lafaille: The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
Dan R. Littman: The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine

Nature, 2014, vol. 510, issue 7503, 152-156

Abstract: Segmented filamentous bacteria drive the acquisition of the TH17 phenotype in an antigen-specific manner; these findings begin to elucidate how gut-induced TH17 cells can contribute to distal organ-specific autoimmune disease.

Date: 2014
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DOI: 10.1038/nature13279

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