Palladium-catalysed C–H activation of aliphatic amines to give strained nitrogen heterocycles

Andrew McNally, Benjamin Haffemayer, Beatrice S. L. Collins and Matthew J. Gaunt ()
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Andrew McNally: University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
Benjamin Haffemayer: University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
Beatrice S. L. Collins: University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
Matthew J. Gaunt: University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK

Nature, 2014, vol. 510, issue 7503, 129-133

Abstract: A palladium-catalysed C–H bond activation process is reported that proceeds through a four-membered-ring cyclopalladation pathway; it allows a methyl group that is adjacent to an unprotected secondary amine to be transformed into a synthetically versatile nitrogen heterocycle.

Date: 2014
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DOI: 10.1038/nature13389

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