Ubiquitin is phosphorylated by PINK1 to activate parkin

Fumika Koyano, Kei Okatsu, Hidetaka Kosako, Yasushi Tamura, Etsu Go, Mayumi Kimura, Yoko Kimura, Hikaru Tsuchiya, Hidehito Yoshihara, Takatsugu Hirokawa, Toshiya Endo, Edward A. Fon, Jean-François Trempe, Yasushi Saeki, Keiji Tanaka () and Noriyuki Matsuda ()
Additional contact information
Fumika Koyano: Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo 156-8506, Japan
Kei Okatsu: Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo 156-8506, Japan
Hidetaka Kosako: Fujii Memorial Institute of Medical Sciences, The University of Tokushima, Tokushima 770-8503, Japan
Yasushi Tamura: Research Center for Materials Science, Nagoya University, Nagoya, Aichi 464-8602, Japan
Etsu Go: Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo 156-8506, Japan
Mayumi Kimura: Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo 156-8506, Japan
Yoko Kimura: Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo 156-8506, Japan
Hikaru Tsuchiya: Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo 156-8506, Japan
Hidehito Yoshihara: Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo 156-8506, Japan
Takatsugu Hirokawa: Molecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology, 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan
Toshiya Endo: Graduate School of Science, Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan
Edward A. Fon: McGill Parkinson Program, Montreal Neurological Institute and Hospital, McGill University, Montréal, Québec H3A 2B4, Canada
Jean-François Trempe: McGill University, Montréal, Québec H3G 1Y6, Canada
Yasushi Saeki: Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo 156-8506, Japan
Keiji Tanaka: Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo 156-8506, Japan
Noriyuki Matsuda: Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo 156-8506, Japan

Nature, 2014, vol. 510, issue 7503, 162-166

Abstract: Ubiquitin, known for its role in post-translational modification of other proteins, undergoes post-translational modification itself; after a decrease in mitochondrial membrane potential, the kinase enzyme PINK1 phosphorylates ubiquitin at Ser 65, and the phosphorylated ubiquitin then interacts with ubiquitin ligase (E3) enzyme parkin, which is also phosphorylated by PINK1, and this process is sufficient for full activation of parkin enzymatic activity.

Date: 2014
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DOI: 10.1038/nature13392

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