The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress

Peter van Galen, Antonija Kreso, Nathan Mbong, David G. Kent, Timothy Fitzmaurice, Joseph E. Chambers, Stephanie Xie, Elisa Laurenti, Karin Hermans, Kolja Eppert, Stefan J. Marciniak, Jane C. Goodall, Anthony R. Green, Bradly G. Wouters, Erno Wienholds and John E. Dick ()
Additional contact information
Peter van Galen: Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada
Antonija Kreso: Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada
Nathan Mbong: Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada
David G. Kent: Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK
Timothy Fitzmaurice: School of Clinical Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge CB2 0QQ, UK
Joseph E. Chambers: Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK
Stephanie Xie: Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada
Elisa Laurenti: Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada
Karin Hermans: Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada
Kolja Eppert: McGill University and the Research Institute of the McGill University Health Centre, Westmount, Québec H3Z 2Z3, Canada
Stefan J. Marciniak: Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK
Jane C. Goodall: School of Clinical Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge CB2 0QQ, UK
Anthony R. Green: Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK
Bradly G. Wouters: Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada
Erno Wienholds: Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada
John E. Dick: Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada

Nature, 2014, vol. 510, issue 7504, 268-272

Abstract: Molecular, pharmacological and functional data show that haematopoietic stem cells (HSCs) are predisposed to ER-stress-mediated apoptosis compared to closely related progenitors; a framework for understanding how stress signalling is coordinated within the hematopoietic hierarchy and integrated with stemness is provided, and may have implications for the improvement of clinical transplantation of HSCs.

Date: 2014
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DOI: 10.1038/nature13228

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