Quantitative flux analysis reveals folate-dependent NADPH production

Jing Fan, Jiangbin Ye, Jurre J. Kamphorst, Tomer Shlomi, Craig B. Thompson and Joshua D. Rabinowitz ()
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Jing Fan: Princeton University
Jiangbin Ye: Memorial Sloan Kettering Cancer Center
Jurre J. Kamphorst: Princeton University
Tomer Shlomi: Princeton University
Craig B. Thompson: Memorial Sloan Kettering Cancer Center
Joshua D. Rabinowitz: Princeton University

Nature, 2014, vol. 510, issue 7504, 298-302

Abstract: A metabolomics quantification of NADPH production and consumption fluxes in proliferating mammalian cells reveals that, in addition to canonical pathways such as the oxidative pentose phosphate pathway, NADPH can also be produced by a folate metabolism pathway, a discovery providing new insights into the metabolism of cell growth.

Date: 2014
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DOI: 10.1038/nature13236

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