SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer

Pawel K. Mazur, Nicolas Reynoird, Purvesh Khatri, Pascal W. T. C. Jansen, Alex W. Wilkinson, Shichong Liu, Olena Barbash, Glenn S. Van Aller, Michael Huddleston, Dashyant Dhanak, Peter J. Tummino, Ryan G. Kruger, Benjamin A. Garcia, Atul J. Butte, Michiel Vermeulen, Julien Sage () and Or Gozani ()
Additional contact information
Pawel K. Mazur: Stanford University School of Medicine
Nicolas Reynoird: Stanford University
Purvesh Khatri: Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine
Pascal W. T. C. Jansen: University Medical Center Utrecht, 3508 AB Utrecht, The Netherlands
Alex W. Wilkinson: Stanford University
Shichong Liu: Perelman School of Medicine, University of Pennsylvania
Olena Barbash: Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville
Glenn S. Van Aller: Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville
Michael Huddleston: Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville
Dashyant Dhanak: Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville
Peter J. Tummino: Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville
Ryan G. Kruger: Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville
Benjamin A. Garcia: Perelman School of Medicine, University of Pennsylvania
Atul J. Butte: Stanford University School of Medicine
Michiel Vermeulen: University Medical Center Utrecht, 3508 AB Utrecht, The Netherlands
Julien Sage: Stanford University School of Medicine
Or Gozani: Stanford University

Nature, 2014, vol. 510, issue 7504, 283-287

Abstract: SMYD3 is a methyltransferase overexpressed in several human tumours; here methylation of the MAP3K2 kinase by SMYD3 is shown to be critical for Ras-induced tumour development in mouse models and human tumour cells, showing an unexpected role for methylation in a kinase signalling pathway and revealing a candidate therapeutic target.

Date: 2014
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/nature13320 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:510:y:2014:i:7504:d:10.1038_nature13320

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature13320

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().