PTEN action in leukaemia dictated by the tissue microenvironment

Cornelius Miething, Claudio Scuoppo, Benedikt Bosbach, Iris Appelmann, Joy Nakitandwe, Jing Ma, Gang Wu, Laura Lintault, Martina Auer, Prem K. Premsrirut, Julie Teruya-Feldstein, James Hicks, Helene Benveniste, Michael R. Speicher, James R. Downing and Scott W. Lowe ()
Additional contact information
Cornelius Miething: Memorial Sloan Kettering Cancer Center
Claudio Scuoppo: Cold Spring Harbor Laboratory
Benedikt Bosbach: Memorial Sloan Kettering Cancer Center
Iris Appelmann: Memorial Sloan Kettering Cancer Center
Joy Nakitandwe: St. Jude Children’s Research Hospital
Jing Ma: St. Jude Children’s Research Hospital
Gang Wu: St. Jude Children’s Research Hospital
Laura Lintault: Cold Spring Harbor Laboratory
Martina Auer: Institute of Human Genetics, Medical University of Graz, A-8010 Graz, Austria
Prem K. Premsrirut: Cold Spring Harbor Laboratory
Julie Teruya-Feldstein: Memorial Sloan Kettering Cancer Center
James Hicks: Cold Spring Harbor Laboratory
Helene Benveniste: Stony Brook University
Michael R. Speicher: Institute of Human Genetics, Medical University of Graz, A-8010 Graz, Austria
James R. Downing: St. Jude Children’s Research Hospital
Scott W. Lowe: Memorial Sloan Kettering Cancer Center

Nature, 2014, vol. 510, issue 7505, 402-406

Abstract: A mouse model of T-cell leukaemia is used to test whether PTEN loss is required for tumour maintenance as well as initiation; although it had little effect on tumour load in haematopoietic organs, PTEN reactivation reduced the CCR9-dependent tumour dissemination to the intestine that was amplified on PTEN loss, exposing the importance of tumour microenvironment in PTEN-deficient settings.

Date: 2014
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DOI: 10.1038/nature13239

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