mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert

Joseph T. Rodgers, Katherine Y. King, Jamie O. Brett, Melinda J. Cromie, Gregory W. Charville, Katie K. Maguire, Christopher Brunson, Namrata Mastey, Ling Liu, Chang-Ru Tsai, Margaret A. Goodell and Thomas A. Rando ()
Additional contact information
Joseph T. Rodgers: Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
Katherine Y. King: Baylor College of Medicine
Jamie O. Brett: Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
Melinda J. Cromie: Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
Gregory W. Charville: Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
Katie K. Maguire: Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
Christopher Brunson: Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
Namrata Mastey: Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
Ling Liu: Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
Chang-Ru Tsai: Baylor College of Medicine
Margaret A. Goodell: Baylor College of Medicine
Thomas A. Rando: Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine

Nature, 2014, vol. 510, issue 7505, 393-396

Abstract: A mouse study reveals that the stem cell quiescent state is composed of two distinct phases, G0 and GAlert; stem cells reversibly transition between these two phases in response to systemic environmental stimuli acting through the mTORC1 pathway.

Date: 2014
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DOI: 10.1038/nature13255

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