Co-opting sulphur-carrier proteins from primary metabolic pathways for 2-thiosugar biosynthesis

Eita Sasaki, Xuan Zhang, He G. Sun, Mei-Yeh Jade Lu, Tsung-lin Liu, Albert Ou, Jeng-yi Li, Yu-hsiang Chen, Steven E. Ealick and Hung-wen Liu ()
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Eita Sasaki: University of Texas at Austin
Xuan Zhang: Cornell University
He G. Sun: College of Pharmacy, University of Texas at Austin
Mei-Yeh Jade Lu: Biodiversity Research Center, Academia Sinica, Taipei 115, Taiwan
Tsung-lin Liu: Genomics Research Center, Academia Sinica, Taipei 115, Taiwan
Albert Ou: Genomics Research Center, Academia Sinica, Taipei 115, Taiwan
Jeng-yi Li: Biodiversity Research Center, Academia Sinica, Taipei 115, Taiwan
Yu-hsiang Chen: Biodiversity Research Center, Academia Sinica, Taipei 115, Taiwan
Steven E. Ealick: Cornell University
Hung-wen Liu: University of Texas at Austin

Nature, 2014, vol. 510, issue 7505, 427-431

Abstract: How sulphur is incorporated into sulphur-containing secondary metabolites is poorly understood; here, the bacterium Amycolatopsis orientalis is shown to co-opt sulphur-carrier proteins from primary metabolic pathways to facilitate the biosynthesis of sulphur-containing natural products.

Date: 2014
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DOI: 10.1038/nature13256

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