The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

Randall M. Chin, Xudong Fu, Melody Y. Pai, Laurent Vergnes, Heejun Hwang, Gang Deng, Simon Diep, Brett Lomenick, Vijaykumar S. Meli, Gabriela C. Monsalve, Eileen Hu, Stephen A. Whelan, Jennifer X. Wang, Gwanghyun Jung, Gregory M. Solis, Farbod Fazlollahi, Chitrada Kaweeteerawat, Austin Quach, Mahta Nili, Abby S. Krall, Hilary A. Godwin, Helena R. Chang, Kym F. Faull, Feng Guo, Meisheng Jiang, Sunia A. Trauger, Alan Saghatelian, Daniel Braas, Heather R. Christofk, Catherine F. Clarke, Michael A. Teitell, Michael Petrascheck, Karen Reue, Michael E. Jung, Alison R. Frand and Jing Huang ()
Additional contact information
Randall M. Chin: Molecular Biology Institute, University of California Los Angeles
Xudong Fu: University of California Los Angeles
Melody Y. Pai: Molecular Biology Institute, University of California Los Angeles
Laurent Vergnes: University of California Los Angeles
Heejun Hwang: University of California Los Angeles
Gang Deng: University of California Los Angeles
Simon Diep: University of California Los Angeles
Brett Lomenick: University of California Los Angeles
Vijaykumar S. Meli: University of California Los Angeles
Gabriela C. Monsalve: University of California Los Angeles
Eileen Hu: University of California Los Angeles
Stephen A. Whelan: University of California Los Angeles
Jennifer X. Wang: Small Molecule Mass Spectrometry Facility, Harvard University
Gwanghyun Jung: University of California Los Angeles
Gregory M. Solis: The Scripps Research Institute
Farbod Fazlollahi: Pasarow Mass Spectrometry Laboratory, University of California Los Angeles
Chitrada Kaweeteerawat: University of California Los Angeles
Austin Quach: University of California Los Angeles
Mahta Nili: University of California Los Angeles
Abby S. Krall: University of California Los Angeles
Hilary A. Godwin: University of California Los Angeles
Helena R. Chang: University of California Los Angeles
Kym F. Faull: Pasarow Mass Spectrometry Laboratory, University of California Los Angeles
Feng Guo: University of California Los Angeles
Meisheng Jiang: University of California Los Angeles
Sunia A. Trauger: Small Molecule Mass Spectrometry Facility, Harvard University
Alan Saghatelian: Harvard University
Daniel Braas: University of California Los Angeles
Heather R. Christofk: University of California Los Angeles
Catherine F. Clarke: Molecular Biology Institute, University of California Los Angeles
Michael A. Teitell: Molecular Biology Institute, University of California Los Angeles
Michael Petrascheck: The Scripps Research Institute
Karen Reue: Molecular Biology Institute, University of California Los Angeles
Michael E. Jung: Molecular Biology Institute, University of California Los Angeles
Alison R. Frand: University of California Los Angeles
Jing Huang: Molecular Biology Institute, University of California Los Angeles

Nature, 2014, vol. 510, issue 7505, 397-401

Abstract: Ageing in the worm Caenorhabditis elegans is shown to be delayed by supplementation with α-ketoglutarate, an effect that is probably mediated by ATP synthase—which is identified as a direct target of α-ketoglutarate—and target of rapamycin (TOR).

Date: 2014
References: Add references at CitEc
Citations: View citations in EconPapers (4)

Downloads: (external link)
https://www.nature.com/articles/nature13264 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:510:y:2014:i:7505:d:10.1038_nature13264

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature13264

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().