Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing

Volker Hovestadt, David T. W. Jones, Simone Picelli, Wei Wang, Marcel Kool, Paul A. Northcott, Marc Sultan, Katharina Stachurski, Marina Ryzhova, Hans-Jörg Warnatz, Meryem Ralser, Sonja Brun, Jens Bunt, Natalie Jäger, Kortine Kleinheinz, Serap Erkek, Ursula D. Weber, Cynthia C. Bartholomae, Christof von Kalle, Chris Lawerenz, Jürgen Eils, Jan Koster, Rogier Versteeg, Till Milde, Olaf Witt, Sabine Schmidt, Stephan Wolf, Torsten Pietsch, Stefan Rutkowski, Wolfram Scheurlen, Michael D. Taylor, Benedikt Brors, Jörg Felsberg, Guido Reifenberger, Arndt Borkhardt, Hans Lehrach, Robert J. Wechsler-Reya, Roland Eils, Marie-Laure Yaspo, Pablo Landgraf, Andrey Korshunov, Marc Zapatka, Bernhard Radlwimmer (), Stefan M. Pfister () and Peter Lichter ()
Additional contact information
Volker Hovestadt: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany
David T. W. Jones: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Simone Picelli: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Wei Wang: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Marcel Kool: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Paul A. Northcott: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Marc Sultan: Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany
Katharina Stachurski: Hematology and Clinical Immunology, Heinrich Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany
Marina Ryzhova: NN Burdenko Neurosurgical Institute, 4th Tverskaya-Yamskaya 16, Moscow 125047, Russia
Hans-Jörg Warnatz: Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany
Meryem Ralser: Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany
Sonja Brun: Tumor Initiation and Maintenance Program, National Cancer Institute (NCI)–Designated Cancer Center, Sanford-Burnham Medical Research Institute, 2880 Torrey Pines Scenic Drive, La Jolla, California 92037, USA
Jens Bunt: Queensland Brain Institute, University of Queensland, QBI Building, St Lucia, Queensland 4072, Australia
Natalie Jäger: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Kortine Kleinheinz: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Serap Erkek: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Ursula D. Weber: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Cynthia C. Bartholomae: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Christof von Kalle: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Chris Lawerenz: Data Management Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Jürgen Eils: Data Management Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Jan Koster: AMC, University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands
Rogier Versteeg: AMC, University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands
Till Milde: Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany
Olaf Witt: Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany
Sabine Schmidt: Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Stephan Wolf: Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Torsten Pietsch: University of Bonn Medical Center, Sigmund-Freud-Strasse 25, Bonn 53105, Germany
Stefan Rutkowski: University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20246, Germany
Wolfram Scheurlen: Cnopf’sche Kinderklinik, Nürnberg Children’s Hospital, St.-Johannis-Mühlgasse 19, Nürnberg 90419, Germany
Michael D. Taylor: Program in Developmental and Stem Cell Biology, The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
Benedikt Brors: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Jörg Felsberg: Heinrich Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany
Guido Reifenberger: Heinrich Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany
Arndt Borkhardt: Hematology and Clinical Immunology, Heinrich Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany
Hans Lehrach: Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany
Robert J. Wechsler-Reya: Tumor Initiation and Maintenance Program, National Cancer Institute (NCI)–Designated Cancer Center, Sanford-Burnham Medical Research Institute, 2880 Torrey Pines Scenic Drive, La Jolla, California 92037, USA
Roland Eils: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Marie-Laure Yaspo: Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, Berlin 14195, Germany
Pablo Landgraf: Hematology and Clinical Immunology, Heinrich Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany
Andrey Korshunov: University of Heidelberg, Im Neuenheimer Feld 220, Heidelberg 69120, Germany
Marc Zapatka: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Bernhard Radlwimmer: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Stefan M. Pfister: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Peter Lichter: German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany

Nature, 2014, vol. 510, issue 7506, 537-541

Abstract: Medulloblastoma is a malignant childhood brain tumour presenting major clinical challenges; here, a comprehensive genome-wide DNA methylation data set from human and mouse tumours, coupled with analysis of histone modifications, RNA transcripts and genome sequencing, uncovers a wealth of alterations that provide insights into the epigenetic regulation of transcription and genome organization in medulloblastoma pathogenesis.

Date: 2014
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DOI: 10.1038/nature13268

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