Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

Anila K. Madiraju, Derek M. Erion, Yasmeen Rahimi, Xian-Man Zhang, Demetrios T. Braddock, Ronald A. Albright, Brett J. Prigaro, John L. Wood, Sanjay Bhanot, Michael J. MacDonald, Michael J. Jurczak, Joao-Paulo Camporez, Hui-Young Lee, Gary W. Cline, Varman T. Samuel, Richard G. Kibbey and Gerald I. Shulman ()
Additional contact information
Anila K. Madiraju: Yale University School of Medicine
Derek M. Erion: Yale University School of Medicine
Yasmeen Rahimi: Yale University School of Medicine
Xian-Man Zhang: Yale University School of Medicine
Demetrios T. Braddock: Yale University School of Medicine
Ronald A. Albright: Yale University School of Medicine
Brett J. Prigaro: Colorado State University
John L. Wood: Cancer Prevention Research Institute of Texas Scholar, Baylor University
Sanjay Bhanot: Isis Pharmaceuticals, 2855 Gazelle Court
Michael J. MacDonald: University of Wisconsin School of Medicine and Public Health, Madison
Michael J. Jurczak: Yale University School of Medicine
Joao-Paulo Camporez: Yale University School of Medicine
Hui-Young Lee: Yale University School of Medicine
Gary W. Cline: Yale University School of Medicine
Varman T. Samuel: Yale University School of Medicine
Richard G. Kibbey: Yale University School of Medicine
Gerald I. Shulman: Yale University School of Medicine

Nature, 2014, vol. 510, issue 7506, 542-546

Abstract: Metformin treatment of rats at physiologically relevant doses inhibits the redox shuttle enzyme mitochondrial glycerophosphate dehydrogenase.

Date: 2014
References: Add references at CitEc
Citations: View citations in EconPapers (5)

Downloads: (external link)
https://www.nature.com/articles/nature13270 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:510:y:2014:i:7506:d:10.1038_nature13270

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature13270

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().