Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors

Johannes Popow, Jennifer Jurkin, Alexander Schleiffer and Javier Martinez ()
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Johannes Popow: Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA)
Jennifer Jurkin: Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA)
Alexander Schleiffer: IMP/IMBA Bioinformatics Core Facility, Research Institute of Molecular Pathology (IMP)
Javier Martinez: Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA)

Nature, 2014, vol. 511, issue 7507, 104-107

Abstract: Using a phylogenetic approach, the protein archease is identified as being a subunit of the human transfer RNA splicing ligase, and found to be necessary for full ligase activity, in cooperation with DDX1.

Date: 2014
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DOI: 10.1038/nature13284

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