RLIM is dispensable for X-chromosome inactivation in the mouse embryonic epiblast

JongDae Shin, Mary C. Wallingford, Judith Gallant, Chelsea Marcho, Baowei Jiao, Meg Byron, Michael Bossenz, Jeanne B. Lawrence, Stephen N. Jones, Jesse Mager and Ingolf Bach ()
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JongDae Shin: Program in Gene Function and Expression, University of Massachusetts Medical School (UMMS)
Mary C. Wallingford: Veterinary & Animal Sciences, University of Massachusetts Amherst
Judith Gallant: UMMS
Chelsea Marcho: Veterinary & Animal Sciences, University of Massachusetts Amherst
Baowei Jiao: Program in Gene Function and Expression, University of Massachusetts Medical School (UMMS)
Meg Byron: UMMS
Michael Bossenz: Ortenau Klinikum Lahr-Ettenheim, Institut für Pathologie, 77933 Lahr, Germany
Jeanne B. Lawrence: UMMS
Stephen N. Jones: UMMS
Jesse Mager: Veterinary & Animal Sciences, University of Massachusetts Amherst
Ingolf Bach: Program in Gene Function and Expression, University of Massachusetts Medical School (UMMS)

Nature, 2014, vol. 511, issue 7507, 86-89

Abstract: The ubiquitin ligase RLIM is known to activate the long non-coding RNA Xist, which is crucial for X-chromosome inactivation in female mice; however, unlike imprinted X-chromosome inactivation that requires RLIM for Xist expression, evidence is now provided that during random X-chromosome inactivation Xist expression is regulated by an RLIM-independent pathway in vivo.

Date: 2014
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DOI: 10.1038/nature13286

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