Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission

T. Karayannis, E. Au, J. C. Patel, I. Kruglikov, S. Markx, R. Delorme, D. Héron, D. Salomon, J. Glessner, S. Restituito, A. Gordon, L. Rodriguez-Murillo, N. C. Roy, J. A. Gogos, B. Rudy, M. E. Rice, M. Karayiorgou, H. Hakonarson, B. Keren, G. Huguet, T. Bourgeron, C. Hoeffer, R. W. Tsien, E. Peles and G. Fishell ()
Additional contact information
T. Karayannis: NYU Neuroscience Institute
E. Au: NYU Neuroscience Institute
J. C. Patel: Neuroscience and Physiology, New York University Langone Medical Center
I. Kruglikov: NYU Neuroscience Institute
S. Markx: College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, New York 10032, USA
R. Delorme: Institut Pasteur, Human Genetics and Cognitive Functions Unit, 75724 Paris, France
D. Héron: Unité Fonctionnelle de Génétique Médicale AP-HP, Centre de Référence, Déficiences intellectuelles de causes rares, CRicm, UMR-S975, Groupe Hospitalier Pitié-Salpêtrière, F-75013, Paris, France
D. Salomon: Weizmann Institute of Science, Rehovot 76100, Israel
J. Glessner: Center for Applied Genomics, The Children’s Hospital of Philadelphia
S. Restituito: NYU Neuroscience Institute
A. Gordon: Weizmann Institute of Science, Rehovot 76100, Israel
L. Rodriguez-Murillo: College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, New York 10032, USA
N. C. Roy: NYU Neuroscience Institute
J. A. Gogos: Columbia University Medical Center
B. Rudy: NYU Neuroscience Institute
M. E. Rice: Neuroscience and Physiology, New York University Langone Medical Center
M. Karayiorgou: College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, New York 10032, USA
H. Hakonarson: Institut Pasteur, Human Genetics and Cognitive Functions Unit, 75724 Paris, France
B. Keren: Unité Fonctionnelle de Génétique Chromosomique AP-HP, CRicm, UMR-S975, Groupe Hospitalier, Pitié-Salpêtrière, 75013 Paris, France
G. Huguet: Institut Pasteur, Human Genetics and Cognitive Functions Unit, 75724 Paris, France
T. Bourgeron: Institut Pasteur, Human Genetics and Cognitive Functions Unit, 75724 Paris, France
C. Hoeffer: NYU Neuroscience Institute
R. W. Tsien: NYU Neuroscience Institute
E. Peles: Weizmann Institute of Science, Rehovot 76100, Israel
G. Fishell: NYU Neuroscience Institute

Nature, 2014, vol. 511, issue 7508, 236-240

Abstract: The molecular relationship between synaptic dysfunction and psychiatric disorders was investigated using a mouse model system; presynaptically localized Cntnap4 is required for the output of two disease-relevant neuronal subpopulations (cortical parvalbumin-positive GABAergic cells and midbrain dopaminergic neurons) and Cntnap4 mutants show behavioural abnormalities which can be pharmacologically reversed.

Date: 2014
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DOI: 10.1038/nature13248

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