SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma

Soufiane Boumahdi, Gregory Driessens, Gaelle Lapouge, Sandrine Rorive, Dany Nassar, Marie Le Mercier, Benjamin Delatte, Amélie Caauwe, Sandrine Lenglez, Erwin Nkusi, Sylvain Brohée, Isabelle Salmon, Christine Dubois, Veronique del Marmol, Francois Fuks, Benjamin Beck and Cédric Blanpain ()
Additional contact information
Soufiane Boumahdi: Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium
Gregory Driessens: Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium
Gaelle Lapouge: Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium
Sandrine Rorive: Erasme Hospital, Université Libre de Bruxelles, Brussels B-1070, Belgium
Dany Nassar: Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium
Marie Le Mercier: Erasme Hospital, Université Libre de Bruxelles, Brussels B-1070, Belgium
Benjamin Delatte: Laboratory of Cancer Epigenetics, Université Libre de Bruxelles, Brussels B-1070, Belgium
Amélie Caauwe: Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium
Sandrine Lenglez: Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium
Erwin Nkusi: Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium
Sylvain Brohée: Machine Learning Group, Faculté des Sciences, Université Libre de Bruxelles, Brussels B-1050, Belgium
Isabelle Salmon: Erasme Hospital, Université Libre de Bruxelles, Brussels B-1070, Belgium
Christine Dubois: Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium
Veronique del Marmol: Erasme Hospital, Université Libre de Bruxelles, Brussels B-1070, Belgium
Francois Fuks: Laboratory of Cancer Epigenetics, Université Libre de Bruxelles, Brussels B-1070, Belgium
Benjamin Beck: Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium
Cédric Blanpain: Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium

Nature, 2014, vol. 511, issue 7508, 246-250

Abstract: Here, in a mouse model of skin squamous cell carcinoma, a key role is demonstrated for the transcription factor SOX2 in the initiation and progression of skin tumours.

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:511:y:2014:i:7508:d:10.1038_nature13305

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DOI: 10.1038/nature13305

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