TH2 and Treg candidate genes in elephant shark

Johannes M. Dijkstra ()
Additional contact information
Johannes M. Dijkstra: Institute for Comprehensive Medical Science, Fujita Health University, Dengaku-gakubo 1-98, 470-1192 Toyoake, Aichi, Japan

Nature, 2014, vol. 511, issue 7508, E7-E9

Abstract: Abstract Arising from B. Venkatesh et al. Nature 505, 174–179 10.1038/nature12826 (2014) Recently in this journal, Venkatesh and co-workers published their analysis of the elephant shark (Callorhinchus milii, a chimaera) genome sequence1. Their analyses suggested that at the evolutionary level of cartilaginous fish, only a primordial T-helper-cell (TH-cell) system was established, geared towards a TH1-type response, because they could not find several important candidate genes, or gene features, necessary for other types of TH cells. However, in contrast to Venkatesh and co-workers, I am able to find elephant shark candidate genes for interleukin-2 (IL-2), IL-4, IL-5 and IL-13, which have important roles in mammalian TH2 and T-regulatory-cell (Treg-cell) systems; furthermore, I feel that claims by the authors of absent CD4 and FOXP3 functions in cartilaginous fish are insufficiently substantiated. Therefore, I believe that major conclusions by the authors regarding proposed unique features of the T-cell system in the elephant shark are based on false arguments, or, as in the case of their CD4 model, are premature. There is a Reply to this Brief Communication Arising by Venkatesh, B. et al. Nature 511,http://dx.doi.org/10.1038/nature13447(2014) .

Date: 2014
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature13446 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:511:y:2014:i:7508:d:10.1038_nature13446

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature13446

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().