BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2

Vaibhav Bhatia, Sonia I. Barroso, María L. García-Rubio, Emanuela Tumini, Emilia Herrera-Moyano and Andrés Aguilera ()
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Vaibhav Bhatia: Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Avenida Américo Vespucio s/n, 41092 Seville, Spain
Sonia I. Barroso: Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Avenida Américo Vespucio s/n, 41092 Seville, Spain
María L. García-Rubio: Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Avenida Américo Vespucio s/n, 41092 Seville, Spain
Emanuela Tumini: Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Avenida Américo Vespucio s/n, 41092 Seville, Spain
Emilia Herrera-Moyano: Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Avenida Américo Vespucio s/n, 41092 Seville, Spain
Andrés Aguilera: Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Avenida Américo Vespucio s/n, 41092 Seville, Spain

Nature, 2014, vol. 511, issue 7509, 362-365

Abstract: BRCA2, the breast cancer susceptibility gene factor, interacts with TREX-2, a protein complex involved in the biogenesis and export of messenger ribonucleoprotein, to process DNA–RNA hybrid structures called R-loops that can trigger genome instability; these may be a central cause of the stress occurring in early cancer cells that drives oncogenesis.

Date: 2014
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DOI: 10.1038/nature13374

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