ABCB5 is a limbal stem cell gene required for corneal development and repair

Bruce R. Ksander, Paraskevi E. Kolovou, Brian J. Wilson, Karim R. Saab, Qin Guo, Jie Ma, Sean P. McGuire, Meredith S. Gregory, William J. B. Vincent, Victor L. Perez, Fernando Cruz-Guilloty, Winston W. Y. Kao, Mindy K. Call, Budd A. Tucker, Qian Zhan, George F. Murphy, Kira L. Lathrop, Clemens Alt, Luke J. Mortensen, Charles P. Lin, James D. Zieske, Markus H. Frank () and Natasha Y. Frank ()
Additional contact information
Bruce R. Ksander: Schepens Eye Research Institute, Massachusetts Eye & Ear Infirmary and Harvard Medical School
Paraskevi E. Kolovou: Schepens Eye Research Institute, Massachusetts Eye & Ear Infirmary and Harvard Medical School
Brian J. Wilson: Transplant Research Program, Boston Children’s Hospital
Karim R. Saab: Transplant Research Program, Boston Children’s Hospital
Qin Guo: Transplant Research Program, Boston Children’s Hospital
Jie Ma: Transplant Research Program, Boston Children’s Hospital
Sean P. McGuire: Schepens Eye Research Institute, Massachusetts Eye & Ear Infirmary and Harvard Medical School
Meredith S. Gregory: Schepens Eye Research Institute, Massachusetts Eye & Ear Infirmary and Harvard Medical School
William J. B. Vincent: Schepens Eye Research Institute, Massachusetts Eye & Ear Infirmary and Harvard Medical School
Victor L. Perez: University of Miami Miller School of Medicine
Fernando Cruz-Guilloty: University of Miami Miller School of Medicine
Winston W. Y. Kao: University of Cincinnati Medical Center
Mindy K. Call: University of Cincinnati Medical Center
Budd A. Tucker: Stephen A Wynn Institute for Vision Research, Carver College of Medicine, University of Iowa
Qian Zhan: Brigham and Women’s Hospital
George F. Murphy: Brigham and Women’s Hospital
Kira L. Lathrop: University of Pittsburgh Swanson School of Engineering
Clemens Alt: Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School
Luke J. Mortensen: Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School
Charles P. Lin: Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School
James D. Zieske: Schepens Eye Research Institute, Massachusetts Eye & Ear Infirmary and Harvard Medical School
Markus H. Frank: Transplant Research Program, Boston Children’s Hospital
Natasha Y. Frank: Transplant Research Program, Boston Children’s Hospital

Nature, 2014, vol. 511, issue 7509, 353-357

Abstract: The loss of limbal stem cells (LSCs) due to injury or disease is one of the leading causes of blindness; here, the ABCB5 protein is identified as a marker of LSCs in mouse and human eye, and shown to be functionally required for LSC maintenance, corneal development and repair.

Date: 2014
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DOI: 10.1038/nature13426

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