WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis

Hong Ouyang, Yuanchao Xue, Ying Lin, Xiaohui Zhang, Lei Xi, Sherrina Patel, Huimin Cai, Jing Luo, Meixia Zhang, Ming Zhang, Yang Yang, Gen Li, Hairi Li, Wei Jiang, Emily Yeh, Jonathan Lin, Michelle Pei, Jin Zhu, Guiqun Cao, Liangfang Zhang, Benjamin Yu, Shaochen Chen, Xiang-Dong Fu (), Yizhi Liu () and Kang Zhang ()
Additional contact information
Hong Ouyang: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
Yuanchao Xue: University of California San Diego
Ying Lin: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
Xiaohui Zhang: and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego
Lei Xi: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
Sherrina Patel: and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego
Huimin Cai: Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan 610041, China
Jing Luo: and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego
Meixia Zhang: Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan 610041, China
Ming Zhang: Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan 610041, China
Yang Yang: and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego
Gen Li: Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan 610041, China
Hairi Li: University of California San Diego
Wei Jiang: Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan 610041, China
Emily Yeh: and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego
Jonathan Lin: and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego
Michelle Pei: and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego
Jin Zhu: and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego
Guiqun Cao: Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan 610041, China
Liangfang Zhang: and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego
Benjamin Yu: University of California San Diego
Shaochen Chen: and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego
Xiang-Dong Fu: and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego
Yizhi Liu: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
Kang Zhang: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University

Nature, 2014, vol. 511, issue 7509, 358-361

Abstract: p63 and PAX6 act to specify limbal stem or progenitor cells (LSCs), and WNT7A controls corneal epithelium differentiation through PAX6; loss of WNT7A or PAX6 induces LSCs into epithelium, and transduction of PAX6 in skin epithelial stem cells converts them to LSC-like cells and transplantation in a rabbit corneal injury model can replenish corneal epithelial cells and repair damaged corneal surface.

Date: 2014
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DOI: 10.1038/nature13465

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