Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53

Amaya Viros, Berta Sanchez-Laorden, Malin Pedersen, Simon J. Furney, Joel Rae, Kate Hogan, Sarah Ejiama, Maria Romina Girotti, Martin Cook, Nathalie Dhomen and Richard Marais ()
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Amaya Viros: Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
Berta Sanchez-Laorden: Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
Malin Pedersen: Signal Transduction Team, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
Simon J. Furney: Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
Joel Rae: Signal Transduction Team, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
Kate Hogan: Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
Sarah Ejiama: Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
Maria Romina Girotti: Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
Martin Cook: Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
Nathalie Dhomen: Signal Transduction Team, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
Richard Marais: Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK

Nature, 2014, vol. 511, issue 7510, 478-482

Abstract: Exposing mice with the BRAF (V600E) mutation to levels of ultraviolet radiation that mimic mild sunburn in humans is shown to induce mutations in the tumour suppressor Trp53 (TP53 in humans), accelerating the development of melanoma; these results support the use of sunscreen in individuals at risk of this cancer.

Date: 2014
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DOI: 10.1038/nature13298

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