C. elegans Punctin specifies cholinergic versus GABAergic identity of postsynaptic domains

Bérangère Pinan-Lucarré, Haijun Tu, Marie Pierron, Pablo Ibáñez Cruceyra, Hong Zhan, Christian Stigloher, Janet E. Richmond and Jean-Louis Bessereau ()
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Bérangère Pinan-Lucarré: Institute of Biology, École Normale Supérieure, 75005 Paris, France
Haijun Tu: Institute of Biology, École Normale Supérieure, 75005 Paris, France
Marie Pierron: Institute of Biology, École Normale Supérieure, 75005 Paris, France
Pablo Ibáñez Cruceyra: Institute of Biology, École Normale Supérieure, 75005 Paris, France
Hong Zhan: Institute of Biology, École Normale Supérieure, 75005 Paris, France
Christian Stigloher: Institute of Biology, École Normale Supérieure, 75005 Paris, France
Janet E. Richmond: University of Illinois at Chicago
Jean-Louis Bessereau: Institute of Biology, École Normale Supérieure, 75005 Paris, France

Nature, 2014, vol. 511, issue 7510, 466-470

Abstract: Two presynaptically secreted isoforms of the protein Punctin in the nematode Caenorhabditis elegans determine the postsynaptic accumulation of acetylcholine versus GABA receptors, raising the question of whether the related human punctin-2 gene, which has been associated with schizophrenia, may also control synaptic organization.

Date: 2014
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DOI: 10.1038/nature13313

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